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Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
Published on: June 21, 2016
Echocardiographic assessment of takotsubo cardiomyopathy: beyond apical ballooning
1First Department of Internal Medicine, Nara Medical University, 840 Shijo, Kashihara, Nara, 634-8522, Japan. hokura@fides.dti.ne.jp.
Insights
Echocardiography is crucial for diagnosing takotsubo cardiomyopathy (TC), revealing diverse wall motion abnormalities beyond apical ballooning. This imaging technique also detects TC complications and aids in differentiating it from other cardiac conditions.
Area of Science:
- Cardiology
- Diagnostic Imaging
Background:
- Takotsubo cardiomyopathy (TC) has been recognized for over 25 years.
- Echocardiography has evolved beyond detecting apical ballooning in TC.
- Left ventriculography was the initial method for visualizing TC's characteristic wall motion abnormalities.
Purpose of the Study:
- To highlight the expanded role of echocardiography in diagnosing takotsubo cardiomyopathy.
- To emphasize echocardiography's utility in identifying diverse findings beyond apical ballooning.
- To showcase echocardiography's capability in detecting TC complications and differentiating it from other conditions.
Main Methods:
- Echocardiography for assessing left ventricular (LV) wall motion abnormalities, including mid-ventricular patterns.
- Evaluation of echocardiographic findings for differentiating TC from acute coronary syndrome and myocarditis.
- Assessment of complications like mitral regurgitation, LV thrombus, and right ventricular (RV) involvement using echocardiography.
Main Results:
- Apical ballooning is not a mandatory diagnostic feature of TC; mid-ventricular asynergy is a common pattern.
- Echocardiography effectively visualizes the distribution and temporal course of LV asynergy.
- Right ventricular involvement is a frequent finding in TC, correlating with poorer prognosis.
Conclusions:
- Echocardiography is indispensable for detecting various dynamic findings in TC, extending beyond apical ballooning.
- This modality provides critical information for differential diagnosis and complication detection in TC.
- Advanced echocardiographic techniques may offer further insights into TC pathophysiology and prognosis.
Abstract:
It has been >25 years since the first report of the takotsubo cardiomyopathy (TC). Although left ventriculography was originally used to depict its typical and impressive wall motion abnormality mimicking "takotsubo", or octopus pot, echocardiography plays a pivotal role in detecting not only its left ventricular (LV) wall motion abnormality, apical ballooning, but also various other findings. First of all, apical ballooning is not an essential finding for TC anymore. Mid-ventricular LV asynergy with or without apical involvement is a basic pattern of the LV wall motion abnormality. Distribution and time course of the asynergy may be best detected by echocardiography and echo provides useful information to differentiate between TC and acute coronary syndrome or acute myocarditis. In addition to the wall motion assessment, echo detects complications of TC such as systolic anterior motion of the mitral leaflet with or without LV outflow obstruction, mitral regurgitation, LV thrombus, right ventricular (RV) involvement. In particular, RV involvement is not an uncommon finding and is associated with worse short-term as well as long-term prognosis. Finally, coronary flow measurements and speckle tracking by echo may offer additional and useful information about pathophysiology and prognosis of TC. In conclusion, echocardiography is a standard imaging modality for detecting various dynamic findings beyond apical ballooning in patients with TC.
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