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Axitinib-induced proteinuria and efficacy in patients with metastatic renal cell carcinoma

Masahiro Nozawa1, Koichi Sugimoto2, Takayuki Ohzeki2

  • 1Department of Urology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan. nozawa06@med.kindai.ac.jp.

International Journal of Clinical Oncology
|December 24, 2015
PubMed
Abstract

Insights

Axitinib-induced proteinuria did not predict treatment efficacy or survival in metastatic renal cell carcinoma (mRCC) patients. Urinary protein levels did not correlate with objective response, progression-free survival, or overall survival in this study.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Metastatic renal cell carcinoma (mRCC) is a complex cancer with varied treatment responses.
  • Axitinib is a targeted therapy used for mRCC, but predictive biomarkers are needed.
  • The role of axitinib-induced proteinuria as a predictive biomarker in mRCC remains unevaluated.

Purpose of the Study:

  • To investigate whether axitinib-induced proteinuria can serve as a biomarker for predicting treatment efficacy and survival in patients with mRCC.
  • To analyze the association between urinary protein changes and clinical outcomes in mRCC patients receiving axitinib.

Main Methods:

  • Retrospective review of clinical records for 45 mRCC patients treated with axitinib.
  • Analysis of baseline characteristics, urinary protein status, tumor response, progression-free survival (PFS), and overall survival (OS).
  • Multivariate analysis to identify significant predictors of PFS and OS.

Main Results:

  • No significant difference in tumor shrinkage rates or objective response rates between patients with urinary protein increases ≥+2 and <+2.
  • Median PFS and OS times were similar between the two urinary protein groups.
  • Maximum tumor shrinkage rate, number of metastatic sites, and MSKCC risk were significantly associated with PFS and OS.

Conclusions:

  • The degree of urinary protein increase during axitinib treatment is not associated with objective response, PFS, or OS in mRCC patients.
  • Axitinib-induced proteinuria is not a reliable biomarker for predicting treatment outcomes in this patient cohort.
Keywords:
AxitinibBiomarkerPrognostic factorProteinuriaRenal cell carcinomaTumor shrinkage

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