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Related Experiment Videos

Fetal hyperinsulinism in anencephaly.

C Hubinont1, N M Fisk, U Nicolini

  • 1Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Queen Charlotte's and Chelsea Hospital, London, England.

American Journal of Obstetrics and Gynecology
|August 1, 1989
PubMed
Summary

Anencephalic fetuses exhibit hyperinsulinism, potentially due to reduced glucose utilization without a developed brain. This condition may explain normal fetal growth despite the absence of the hypothalamohypophysial axis.

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Area of Science:

  • Biomedical Science
  • Developmental Biology
  • Endocrinology

Background:

  • Anencephaly is a severe congenital disorder characterized by the absence of a major portion of the brain, skull, and scalp.
  • The role of insulin and glucose metabolism in fetal development, particularly in conditions with significant brain malformations, remains incompletely understood.

Purpose of the Study:

  • To investigate insulin levels in anencephalic fetuses during the mid-trimester.
  • To explore the potential link between observed hyperinsulinism and fetal growth in the context of anencephaly.

Main Methods:

  • Blood samples were collected in utero from three anencephalic fetuses during the mid-trimester.
  • Insulin levels were measured in the collected blood samples.

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Main Results:

  • Elevated insulin levels (hyperinsulinism) were detected in the blood of anencephalic fetuses.
  • The findings suggest a possible alteration in glucose metabolism in these fetuses.

Conclusions:

  • The observed hyperinsulinism in anencephalic fetuses may result from underutilization of glucose due to the absence of a significant portion of the brain.
  • This metabolic state could contribute to the relatively normal fetal growth observed in anencephaly, even without a functional hypothalamohypophysial axis.