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Misuse of Methylphenidate.

David B Clemow1

  • 1Senior Clinical Research Scientist, Lilly Corporate Center, 46285, Indianapolis, IN, USA. davidclemow@lilly.com.

Current Topics in Behavioral Neurosciences
|December 24, 2015
PubMed
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Methylphenidate misuse and diversion are significant issues, particularly among students misusing it for academic or recreational purposes. Close monitoring of prescription methylphenidate is crucial to mitigate these risks.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Methylphenidate is a prescription stimulant for Attention-Deficit/Hyperactivity Disorder (ADHD).
  • Its mechanism involves dopamine elevation, contributing to both therapeutic effects and abuse potential.
  • Nonmedical use for cognitive enhancement or recreational purposes is a growing concern.

Purpose of the Study:

  • To review methylphenidate misuse, abuse, dependence, diversion, and malingering.
  • To examine the effects of methylphenidate in patients with comorbid substance use disorder.
  • To assess the potential linkage between methylphenidate use and subsequent substance abuse.

Main Methods:

  • Literature review of methylphenidate misuse, abuse, and diversion.
  • Analysis of data on prevalence among student populations.
Keywords:
ADHDAbuseDependenceDiversionMalingeringMethylphenidateMisuse

Related Experiment Videos

  • Discussion of diagnostic challenges, including malingering detection.

    • Main Results:

    • Methylphenidate misuse and diversion are prevalent healthcare problems.
    • Stimulant prescription drug diversion affects 5-10% of high school and 5-35% of college students.
    • Methylphenidate is misused for academic enhancement and recreationally.

    Conclusions:

    • Detecting malingering for illicit methylphenidate access is challenging.
    • Methylphenidate use may be linked to subsequent substance abuse.
    • Close screening and therapeutic monitoring of methylphenidate are necessary for ADHD treatment.