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Updated: Mar 28, 2026

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
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Flow chemistry vs. flow analysis.

Marek Trojanowicz1

  • 1Laboratory of Nuclear Analytical Methods, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland; Department of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.

Talanta
|December 24, 2015
PubMed
Summary

Continuous flow synthesis uses real-time analytical monitoring for efficient chemical processes. This review explores advancements and future directions in flow chemistry and its analytical applications.

Area of Science:

  • Chemistry
  • Chemical Engineering
  • Analytical Chemistry

Background:

  • Flow chemistry integrates on-line monitoring, solid-supported reagents, and automated control for efficient chemical synthesis.
  • Flow analysis is a well-established technique in modern analytical chemistry.
  • Continuous flow synthesis shares key attributes with flow analysis.

Purpose of the Study:

  • To review the fundamental aspects, instrumental achievements, and developmental trends in continuous flow chemical synthesis.
  • To highlight the synergy between flow synthesis and flow analysis.
  • To discuss the application of flow analytical measurements for on-line monitoring of flow syntheses.

Main Methods:

  • Literature review based on 131 references (original papers and reviews).

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  • Analysis of instrumental advancements in continuous flow synthesis.
  • Examination of developmental directions in the field.
  • Identification of applications of flow analysis in monitoring flow synthesis.

    • Main Results:

    • Continuous flow synthesis offers advantages in process control and efficiency.
    • Many advancements in flow synthesis can be adapted for flow analysis.
    • On-line analytical measurements are crucial for real-time monitoring of flow syntheses.
    • The field of continuous flow chemical synthesis is rapidly expanding.

    Conclusions:

    • Continuous flow synthesis represents a significant advancement in chemical processing.
    • There is substantial potential for integrating flow analysis techniques into flow synthesis.
    • Real-time analytical measurements are key to optimizing and advancing flow chemistry.
    • Further development is expected in this interdisciplinary field.