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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

109
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
109
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

96
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

115
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
115
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

970
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

250
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Related Experiment Video

Updated: Mar 28, 2026

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery
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Living Cell Factories - Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery.

Syeda M Naqvi1,2, Srujana Vedicherla1,3, Jennifer Gansau1,2

  • 1Trinity Center for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.

Advanced Materials (Deerfield Beach, Fla.)
|December 24, 2015
PubMed
Summary
This summary is machine-generated.

Electrohydrodynamic (EHD) spraying enables minimally invasive delivery of "living cell factories" for advanced biomaterial devices. This technology precisely controls micro-scale biopolymeric systems for diverse therapeutic applications.

Keywords:
electrohydrodynamichydrogelsmicrocapsules, core-shellmicrocarriers

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Area of Science:

  • Biomaterials Science
  • Biotechnology
  • Regenerative Medicine

Background:

  • Minimally invasive delivery of cellular therapeutics is crucial for next-generation biomaterial devices.
  • Cellular microcapsules and microcarriers are promising systems for applications in tissue regeneration, diabetes, and cancer.
  • Electrohydrodynamic (EHD) spraying is a key technology for fabricating these advanced cellular systems.

Purpose of the Study:

  • To outline advances in EHD technology for creating minimally invasive, micro-scaled biopolymeric systems.
  • To highlight the manipulation of bioactive materials for controlled size, composition, and configuration.
  • To present therapeutic applications, future perspectives, and challenges of EHD spraying in biomaterial devices.

Main Methods:

  • Utilizing electrohydrodynamic (EHD) spraying to fabricate micro-scaled biopolymeric systems.
  • Controlling fabrication parameters such as applied voltage, biomaterial viscosity and conductivity, and needle geometry.
  • Manipulating bioactive and dynamic material systems for precise structural control.

Main Results:

  • EHD spraying allows for the fabrication of complex structures and arrangements of cellular systems.
  • The technology enables precise control over the size, composition, and configuration of micro-scaled biopolymeric systems.
  • Advances facilitate the development of minimally invasive delivery systems for therapeutic applications.

Conclusions:

  • EHD spraying is a versatile technology for creating advanced cellular microcapsules and microcarriers.
  • This technique offers significant potential for minimally invasive therapeutic strategies in various medical fields.
  • Further research and development are needed to address associated challenges and fully realize the potential of EHD technology.