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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

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Practice Bulletin No. 160 Summary: Premature Rupture of Membranes

    Obstetrics and Gynecology
    |December 24, 2015
    PubMed

    Insights

    Preterm premature rupture of membranes (PROM) affects 3% of US pregnancies. Management guidelines are presented, balancing delivery risks against expectant management, considering gestational age and outcomes.

    Area of Science:

    • Obstetrics and Gynecology
    • Perinatal Medicine

    Background:

    • Preterm delivery is a significant cause of perinatal morbidity and mortality in the US.
    • Preterm premature rupture of membranes (PROM) complicates approximately 3% of pregnancies.

    Purpose of the Study:

    • To review current understanding of preterm PROM.
    • To provide evidence-based and consensus-based management guidelines.

    Main Methods:

    • Review of current literature and outcome-based research.
    • Incorporation of expert opinion for guideline development.

    Main Results:

    • Optimal clinical assessment and treatment for PROM remain debated.
    • Management decisions weigh risks of delivery against expectant management (e.g., infection).

    Conclusions:

    • Guidelines are provided to aid in the management of PROM.
    • Management strategies consider gestational age and potential complications.

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