Related Experiment Video

Updated: Mar 28, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

12.0K

Practice Bulletin No. 160: Premature Rupture of Membranes

    Obstetrics and Gynecology
    |December 24, 2015
    PubMed

    Insights

    Preterm premature rupture of membranes (PROM) affects 3% of US pregnancies. Management guidelines are presented, balancing delivery risks against expectant management for optimal perinatal outcomes.

    Area of Science:

    • Obstetrics and Gynecology
    • Perinatal Medicine

    Background:

    • Preterm delivery impacts 12% of US births, contributing to perinatal morbidity and mortality.
    • Preterm premature rupture of membranes (PROM) complicates 3% of US pregnancies.
    • Optimal management for PROM remains debated, balancing delivery risks with expectant management concerns like infection.

    Purpose of the Study:

    • To review current understanding of preterm premature rupture of membranes (PROM).
    • To provide evidence-based and consensus-driven management guidelines for PROM.
    • To inform clinical assessment and treatment strategies for women with PROM.

    Main Methods:

    • Literature review of outcome-based research on PROM management.
    • Synthesis of current understanding and expert opinion.
    • Development of clinical guidelines based on available evidence.

    Main Results:

    • Management decisions for PROM require careful consideration of gestational age.
    • Risk assessment involves comparing risks of delivery versus expectant management (infection, abruption, cord accident).
    • Guidelines incorporate both validated research and expert consensus.

    Conclusions:

    • Effective PROM management necessitates a thorough understanding of risks and benefits.
    • Guidelines aim to standardize and improve care for PROM.
    • Further outcome-based research is valuable for refining PROM management strategies.

    More Related Videos

    A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development08:50

    A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

    Published on: June 24, 2020

    4.4K
    Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles05:31

    Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

    Published on: January 26, 2024

    1.5K

    Related Concept Videos

    Development of the Oral Microbiota01:28

    Development of the Oral Microbiota

    The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
    25
    Types of Membrane Protrusions01:28

    Types of Membrane Protrusions

    The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
    The microvilli, an example of stable protrusions, are finger-like projections...
    3.9K
    Mitral Valve Prolapse III: Nursing Management01:19

    Mitral Valve Prolapse III: Nursing Management

    The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
    529
    Menses Phase01:18

    Menses Phase

    The uterine cycle begins with the menstrual phase, which is considered day one of the cycle and typically lasts about five days. This phase is characterized by the degeneration and shedding of the stratum functionalis, the functional layer of the endometrium.
    When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
    1.4K