Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

31.9K
Overview
31.9K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.7K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.7K
Hypersensitivities01:30

Hypersensitivities

7.0K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.0K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.0K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.0K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.3K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-ACTH antibodies in critically ill Covid-19 patients: A potential immune evasion mechanism of SARS-CoV-2.

Medicina intensiva·2022
Same author

Anti-ACTH antibodies in critically ill Covid-19 patients: A potential immune evasion mechanism of SARS-CoV-2.

Medicina intensiva·2021
Same author

Does Rapid Drug Desensitization to Chemotherapy Affect Survival Outcomes?

Journal of investigational allergology & clinical immunology·2019
Same author

Chemotherapy in Mastocytosis: Administration Issues, Hypersensitivity, and Rapid Drug Desensitization.

Journal of investigational allergology & clinical immunology·2017
Same author

[Hypertrophic osteoarthropathy in lung adenocarcinoma].

Semergen·2016
Same author

Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis.

The pharmacogenomics journal·2015

Related Experiment Video

Updated: Jan 9, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.9K

Rush immunotherapy with a standardized Bermuda grass pollen extract.

A Armentia-Medina1, A Blanco-Quiros, J M Martin-Santos

  • 1Department of Allergy and Clinical Immunology, Hospital Ramon y Cajal, Madrid, Spain.

Annals of Allergy
|August 1, 1989
PubMed
Summary

Immunotherapy significantly reduced Bermuda grass pollen allergy symptoms and bronchial hyperreactivity. Allergy antibody levels increased, demonstrating treatment efficacy in a clinical trial.

More Related Videos

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.2K
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.4K

Related Experiment Videos

Last Updated: Jan 9, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.9K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.2K
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.4K

Area of Science:

  • Allergen immunotherapy
  • Clinical immunology
  • Respiratory medicine

Background:

  • Bermuda grass pollen is a common allergen.
  • Allergic rhinitis and asthma are prevalent conditions.
  • Immunotherapy aims to desensitize patients to allergens.

Purpose of the Study:

  • To evaluate the efficacy of immunotherapy for Bermuda grass pollen sensitization.
  • To assess changes in allergic responses following treatment.

Main Methods:

  • Double-blind, placebo-controlled clinical trial.
  • In vivo tests: skin tests, bronchial hyperreactivity tests.
  • In vitro tests: histamine release, specific IgE and IgG antibody levels.

Main Results:

  • Significant decrease in bronchial hyperreactivity and skin sensitivity.
  • Reduced histamine release in delayed responses.
  • Increased specific IgE and IgG antibodies to Bermuda grass pollen.

Conclusions:

  • Immunotherapy is effective in reducing allergic responses to Bermuda grass pollen.
  • Treatment leads to measurable immunological changes.
  • Placebo group showed no significant improvements.