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Related Experiment Video

Updated: Mar 28, 2026

Analysis of Cardiomyocyte Development using Immunofluorescence in Embryonic Mouse Heart

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Published on: March 26, 2015

Calreticulin in the Heart: From Embryological Development to Cardiac Pathology.

D Martinho-Dias, A Leite-Moreira, P Castro-Chaves¹

¹Physiology and Cardiothoracic Surgery Department, Faculty of Medicine, University of Porto, 4200 Porto, Portugal. pchaves@med.up.pt.

Current Molecular Medicine

|December 24, 2015

Summary

Calreticulin, an endoplasmic reticulum (ER) protein, is vital for heart development in mice. Its altered expression in adult hearts is linked to cardiac pathologies, suggesting therapeutic potential.

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Area of Science:

Cardiovascular Biology
Molecular Cardiology
Developmental Biology

Background:

Calreticulin is a Ca(2+)-binding chaperone in the endoplasmic reticulum (ER).
It plays a critical role in the embryological development of the heart in mice.
Altered calreticulin expression is associated with adult cardiac pathologies like hypertrophy and dilated cardiomyopathy.

Purpose of the Study:

To review the role of calreticulin in mouse heart embryological development.
To clarify the link between cardiac pathologies and altered calreticulin levels in adult hearts.

Main Methods:

Literature review of calreticulin's function in cardiac development and disease.
Analysis of studies correlating calreticulin expression with cardiac pathologies.

Main Results:

Calreticulin is essential for normal heart embryogenesis in mice.
Dysregulation of calreticulin expression in adult hearts contributes to cardiac pathologies.
Specific stimuli can reactivate embryonic transcription patterns, leading to calreticulin overexpression and signaling pathway disruption.

Conclusions:

The endoplasmic reticulum (ER) plays a crucial role in cardiomyocyte embryogenesis.
Reactivation of embryonic transcription patterns can lead to calreticulin overexpression and cardiac pathology.
Targeting these transcriptional abnormalities offers a promising therapeutic strategy for cardiac diseases.