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Published on: October 4, 2024
Antibacterial Property of Graphene Quantum Dots (Both Source Material and Bacterial Shape Matter)
Liwei Hui1, Jianliu Huang1, Guanxiong Chen1
1CAS Key Laboratory of Soft Matter Chemistry, §Department of Materials Science and Engineering, ‡Physics and Chemistry Analysis Laboratory, $CAS Key Laboratory of Materials for Energy Conversion, ¶iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), and #Department of Polymer Science and Engineering, University of Science and Technology of China , Hefei, Anhui 230026 China.
Abstract:
Whereas diverse graphene quantum dots (GQDs) with basal planes similar to those of graphene oxide sheets (i.e., GO-GQDs) lack antibacterial property, that prepared by rupturing C60 cage (i.e., C60-GQD) effectively kills Staphylococcus aureus, including its antibiotic-tolerant persisters, but not Bacillus subtilis, Escherichia coli, or Pseudomonas aeruginosa. The observed activity may correlate with a GQD's ability to disrupt bacterial cell envelop. Surface-Gaussian-curvature match between a GQD and a target bacterium may play critical role in the association of the GQD with bacterial cell surface, the initial step for cell envelope disruption, suggesting the importance of both GQDs' source materials and bacterial shape.
