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Related Experiment Video

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Age-dependent mesial temporal lobe lateralization in language fMRI.

Leigh N Sepeta1,2,3, Madison M Berl1,2,3, Marko Wilke4

  • 1Children's National Health System, Washington, District of Columbia, U.S.A.

Epilepsia
|December 24, 2015
PubMed
Summary

Mesial temporal lobe (MTL) activation during language fMRI is present in children and adults with epilepsy. MTL activation becomes more left-lateralized with age, influencing surgical planning and memory outcomes.

Keywords:
Functional neuroimagingNeuropsychological assessmentSeizures

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Area of Science:

  • Neuroimaging
  • Epilepsy Surgery
  • Developmental Neuroscience

Background:

  • Functional magnetic resonance imaging (fMRI) of the mesial temporal lobe (MTL) is crucial for epilepsy surgical planning.
  • Understanding MTL activation and lateralization during language tasks is essential in pediatric and adult epilepsy patients.

Purpose of the Study:

  • To investigate MTL activation and lateralization during language fMRI in children and adults with focal epilepsy.
  • To compare MTL activation patterns between patients and controls across different age groups.

Main Methods:

  • 142 participants (pediatric and adult controls and epilepsy patients) underwent 3T fMRI using a language task.
  • Image analysis utilized Statistical Parametric Mapping (SPM8) focusing on MTL, Broca's, and Wernicke's areas.
  • Assessed group and individual MTL activation and quantified the degree of lateralization.

Main Results:

  • Both patients and controls showed group and individual MTL activation.
  • Adults exhibited left-lateralized MTL activation, while children showed less lateralization (p < 0.005).
  • Older age correlated with stronger left-lateralized MTL activation; language lateralization predicted MTL lateralization in adults but not children.

Conclusions:

  • Language fMRI effectively elicits group and individual MTL activation.
  • A developmental shift in MTL lateralization occurs with age, increasing leftward lateralization.
  • This developmental shift may explain better memory outcomes in children post-resection compared to adults.