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Related Experiment Videos

Seizure propensity with imipenem.

R H Eng1, A N Munsif, B G Yangco

  • 1Medical Service, Veterans Administration Medical Center, East Orange, NJ 07019.

Archives of Internal Medicine
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

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Imipenem, a potent antibiotic, can cause seizures in patients and mice at lower doses than penicillin or cefotaxime. This risk of neurologic symptoms offsets its strong antibacterial activity.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Infectious Diseases

Background:

  • Imipenem is a broad-spectrum carbapenem antibiotic with potent antibacterial activity.
  • Carbapenems, including imipenem, have been associated with central nervous system adverse effects, such as seizures.
  • Understanding the dose-dependent neurotoxicity of antibiotics is crucial for patient safety.

Observation:

  • Five human patients experienced seizures linked to imipenem administration.
  • A comparative mouse model investigated the seizure-inducing potential of imipenem, penicillin, and cefotaxime.
  • Imipenem induced seizures at a significantly lower mean serum concentration (1900 mcg/mL) compared to penicillin (5800 mcg/mL) and cefotaxime (3400 mcg/mL).

Findings:

  • Imipenem exhibits a higher propensity to induce seizures than penicillin G or cephalosporins like cefotaxime.

Related Experiment Videos

  • The neurotoxic potential of imipenem is observed in both human patients and a murine model.
  • Lower serum concentrations of imipenem are associated with seizure risk.

    • Implications:

    • Clinicians should be aware of the increased risk of seizures with imipenem, especially in patients with predisposing factors.
    • The findings suggest a need for careful dosing and monitoring of imipenem therapy to mitigate neurological side effects.
    • Further research may explore strategies to reduce imipenem-induced neurotoxicity while preserving its efficacy.