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Related Concept Videos

Nervous Tissue: Myelin01:25

Nervous Tissue: Myelin

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The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
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Updated: Mar 28, 2026

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
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Remyelination Therapy in Multiple Sclerosis.

Danielle E Harlow1, Justin M Honce2, Augusto A Miravalle3

  • 1Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus , Aurora, CO , USA.

Frontiers in Neurology
|December 24, 2015
PubMed
Summary
This summary is machine-generated.

New therapies aim to repair myelin damage in multiple sclerosis (MS) by promoting remyelination. Advanced imaging techniques are crucial for evaluating these promising treatments in clinical trials.

Keywords:
DTIMRIMTImultiple sclerosismyelin repairneuroprotectionremyelination

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Area of Science:

  • Neuroscience
  • Immunology
  • Regenerative Medicine

Background:

  • Multiple sclerosis (MS) is a central nervous system disorder causing myelin sheath destruction and neurodegeneration.
  • Current MS treatments focus on immune response modulation for relapsing forms, with limited efficacy in progressive MS.
  • Repairing myelin damage through remyelination is essential for restoring neuronal function and preventing disability.

Purpose of the Study:

  • To review remyelination failure in MS.
  • To discuss strategies for overcoming remyelination failure.
  • To highlight emerging remyelination therapies and advanced imaging techniques for MS.

Main Methods:

  • Review of current literature on MS pathogenesis and treatment.
  • Analysis of preclinical and clinical studies on remyelination therapies.
  • Evaluation of novel imaging technologies for assessing remyelination.

Main Results:

  • Significant progress in understanding myelination mechanisms and identifying potential remyelination agents.
  • Development of new therapeutic candidates in preclinical and early clinical stages.
  • Advancements in imaging technologies enabling better assessment of remyelination in patients.

Conclusions:

  • Remyelination therapies hold promise for progressive MS, addressing a critical unmet need.
  • Improved imaging is vital for the successful clinical development and evaluation of remyelination strategies.
  • Further research and clinical trials are necessary to translate these advancements into effective patient treatments.