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Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery

Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery

Published on: September 27, 2021

Translating Treg Therapy in Humanized Mice.

Susanne A Hahn¹, Iris Bellinghausen¹, Bettina Trinschek¹

¹Department of Dermatology, University Medical Center, Johannes Gutenberg-University , Mainz , Germany.

Frontiers in Immunology

|December 24, 2015

Summary

This summary is machine-generated.

Humanized mouse models enable the study of regulatory T cells (Treg) outside the body. These models are crucial for developing new therapeutic strategies targeting Treg cells for disease intervention.

Keywords:

Treg function autoimmune disease risk humanized mice therapy tolerance

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Area of Science:

Immunology
Cell Biology
Therapeutics

Background:

Regulatory T cells (Treg) possess broad regulatory functions impacting both immune and non-immunological processes.
The therapeutic potential of manipulating Treg cells for disease intervention is significant.
Development of preclinical tools is essential for advancing Treg-based therapeutic strategies.

Purpose of the Study:

To review the current applications of humanized mouse models for studying human Treg cells.
To explore the utility of these models in understanding Treg immunobiology at a molecular level.
To discuss the design of therapeutic strategies leveraging human Treg cells.

Main Methods:

Utilizing humanized mouse models engrafted with human immune cells and tissues.
Analyzing human Treg ontogeny and immunobiology within these models.
Investigating Treg function at the molecular level.

Main Results:

Humanized mouse models offer a platform for in vivo analysis of human Treg biology.
These models facilitate the examination of Treg interactions and functions.
The models are instrumental in preclinical testing of Treg-targeting therapies.

Conclusions:

Humanized mouse models are valuable tools for advancing the understanding of human Treg cells.
These models are critical for developing and validating novel Treg-based therapeutic approaches.
Further research using humanized models will accelerate the translation of Treg therapies into clinical practice.