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The role of progranulin in diabetes and kidney disease

Bruna Bellincanta Nicoletto1, Luis Henrique Canani2

  • 1Post Graduation Medical Sciences Program: Endocrinology, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), 2400 Ramiro Barcelos Street, 2º floor, Porto Alegre, Rio Grande do Sul 90035-003 Brazil.

Diabetology & Metabolic Syndrome
|December 24, 2015
PubMed

Insights

Progranulin (PGRN) is a protein with diverse roles, including anti-inflammatory and neuroprotective actions. Emerging evidence highlights its pro-inflammatory effects in obesity, insulin resistance, and kidney disease.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Metabolic Research

Background:

  • Progranulin (PGRN) is a secreted protein with diverse cellular expression and functions.
  • Initially recognized for growth factor-like, anti-inflammatory, and neuroprotective roles.
  • Recent studies identify PGRN as an adipokine linked to metabolic dysfunction and inflammation.

Purpose of the Study:

  • To discuss the emerging pro-inflammatory roles of PGRN.
  • To explore PGRN's involvement in obesity, insulin resistance, and type 2 diabetes mellitus.
  • To examine the association between PGRN and kidney disease.

Main Methods:

  • Literature review of recent data on PGRN.
  • Discussion of potential mechanisms of PGRN's pro-inflammatory actions.
  • Analysis of PGRN's role in metabolic and renal conditions.

Main Results:

  • PGRN levels are elevated in obesity and type 2 diabetes mellitus.
  • PGRN exhibits pro-inflammatory properties in metabolic contexts.
  • A significant association exists between PGRN and renal disease, though causality is unclear.

Conclusions:

  • PGRN plays multifaceted roles, with emerging pro-inflammatory actions.
  • Further research is needed to elucidate PGRN's distinct functions in various tissues and conditions.
  • Understanding PGRN's inflammatory pathways is crucial for metabolic and kidney disease.

Keywords:
AdipokineDiabetesInflammationKidney diseaseObesityProgranulin

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