Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K
Aging01:26

Aging

1.0K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.0K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

5.0K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
5.0K
Mitochondria01:37

Mitochondria

21.3K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.3K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.8K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
5.8K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.4K
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: The influence of lifestyle factors on cancer biology and treatment efficacy.

Frontiers in physiology·2023
Same author

<i>Ex Vivo</i> treatment of coronary artery endothelial cells with serum post-exercise training offers limited protection against <i>in vitro</i> exposure to FEC-T chemotherapy.

Frontiers in physiology·2023
Same author

Aerobically trained older adults show impaired resting, but preserved exercise-induced circulating progenitor cell count, which was not improved by sprint interval training.

Pflugers Archiv : European journal of physiology·2023
Same author

Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials.

Frontiers in toxicology·2022
Same author

Type 1 Diabetes Patients With Different Residual Beta-Cell Function but Similar Age, HBA1c, and Cardiorespiratory Fitness Have Differing Exercise-Induced Angiogenic Cell Mobilisation.

Frontiers in endocrinology·2022
Same author

Trail Use, Motivations, and Environmental Attitudes of 3780 European Mountain Bikers: What Is Sustainable?

International journal of environmental research and public health·2021

Related Experiment Video

Updated: Mar 28, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

13.3K

Vascular Ageing and Exercise: Focus on Cellular Reparative Processes.

Mark D Ross1, Eva Malone1, Geraint Florida-James1

  • 1School of Life, Sport and Social Sciences, Edinburgh Napier University, Edinburgh EH11 4BN, UK.

Oxidative Medicine and Cellular Longevity
|December 24, 2015
PubMed
Summary

Regular exercise combats vascular ageing by improving endothelial function and boosting endothelial progenitor cells, reducing the risk of cardiovascular disease and diabetes in older adults.

More Related Videos

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
08:03

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model

Published on: June 11, 2017

14.2K
A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice
06:59

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice

Published on: April 28, 2022

5.0K

Related Experiment Videos

Last Updated: Mar 28, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

13.3K
Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model
08:03

Treatment of Ligament Constructs with Exercise-conditioned Serum: A Translational Tissue Engineering Model

Published on: June 11, 2017

14.2K
A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice
06:59

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice

Published on: April 28, 2022

5.0K

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Exercise Physiology

Background:

  • Ageing increases noncommunicable disease (NCD) risk, including diabetes and cardiovascular disease (CVD), often due to oxidative stress.
  • Endothelial dysfunction, characterized by senescence and reduced nitric oxide (NO) production, defines vascular ageing and impairs vascular repair.
  • Reduced numbers and function of endothelial progenitor cells (EPCs) in ageing further compromise the endothelium's ability to repair damage.

Purpose of the Study:

  • To review the impact of ageing on the endothelium and EPCs.
  • To examine how exercise mitigates age-related vascular changes and promotes endothelial health.

Main Methods:

  • Literature review focusing on ageing, endothelial function, EPCs, oxidative stress, and exercise.
  • Analysis of studies investigating the effects of exercise on vascular ageing markers.

Main Results:

  • Exercise protects against CVD and diabetes by improving endothelial function and reducing oxidative stress.
  • Regular physical activity can prevent endothelial senescence and enhance nitric oxide bioavailability.
  • Exercise positively modulates the number and function of EPCs, supporting endothelial repair and homeostasis.

Conclusions:

  • Exercise is a potent strategy to counteract vascular ageing.
  • Maintaining endothelial health through exercise can significantly reduce the risk of age-related NCDs.
  • Exercise interventions can improve endothelial repair mechanisms by enhancing EPC function.