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Methicillin Resistant Staphylococci: Prevalence and susceptibility patterns in a burn center in Ahvaz from 2013-2014

Alireza Ekrami1, Effat Abbasi Montazeri2, Gholam Abbas Kaydani3

  • 1Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. ; Department of Medical laboratory Sciences, School of Para medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Iranian Journal of Microbiology
|December 24, 2015
PubMed
Abstract

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative staphylococci (MRCoNS) are significant threats in burn units. Vancomycin and imipenem show effectiveness against these multi-drug resistant strains.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Burn Care

Background:

  • Nosocomial infections caused by Methicillin-resistant Staphylococcus aureus (MRSA) and Methicillin-resistant coagulase-negative staphylococci (MRCoNS) pose a serious threat to burn patients.
  • Understanding the prevalence and antibiotic resistance patterns of these pathogens is crucial for effective patient management.

Purpose of the Study:

  • To determine the frequency of MRSA and MRCoNS among burn patients.
  • To characterize the antibiotic resistance patterns of these resistant staphylococcal strains.
  • To identify effective therapeutic agents against MRSA and MRCoNS in a burn center in Ahvaz, Iran.

Main Methods:

  • Analysis of 340 clinical specimens (80% wound, 20% blood) from burn patients.
  • Identification of staphylococcal species and antibiotic susceptibility testing using disk diffusion, Etest, and PCR for the mecA gene.

Main Results:

  • Staphylococci were identified in 30.2% of isolates, with 82% being S. aureus and 18% CoNS.
  • Methicillin resistance was observed in 60% of S. aureus and 63% of CoNS isolates.
  • Multi-drug resistance patterns were noted, with Vancomycin and Imipenem showing the highest efficacy against resistant strains.

Conclusions:

  • Multi-drug resistant MRSA and MRCoNS are a significant concern in burn hospital settings.
  • Vancomycin remains a primary choice for treating infections caused by methicillin-resistant staphylococci.
Keywords:
Burn patientsMethicillin ResistanceStaphylococci

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