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Related Experiment Video

Updated: Mar 28, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
04:41

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

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Keloidal Scleroderma: Case Report and Review.

Sama Kassira1, Tarannum Jaleel1, Peter Pavlidakey1

  • 1Department of Dermatology, University of Alabama at Birmingham, EFH 414, 1530 3rd Avenue S, Birmingham, AL 35294, USA.

Case Reports in Dermatological Medicine
|December 24, 2015
PubMed
Summary
This summary is machine-generated.

This study details a rare case of keloidal scleroderma, a condition often mistaken for keloids or scars. Methotrexate showed promise in treating a patient with this progressive skin disorder.

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Last Updated: Mar 28, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
04:41

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

3.8K

Area of Science:

  • Dermatology
  • Rheumatology
  • Autoimmune Diseases

Background:

  • Keloidal scleroderma is a rare variant of morphea (localized scleroderma).
  • It presents as indurated, exophytic nodules and plaques, often confused with keloids or scars.
  • Limited data exists on its clinical presentation and treatment efficacy.

Purpose of the Study:

  • To report a rare case of keloidal scleroderma.
  • To analyze clinical, pathological, and treatment data from similar reported cases.
  • To evaluate potential treatment options for keloidal scleroderma.

Main Methods:

  • Case report of a 41-year-old woman with keloidal scleroderma.
  • Literature review of cases using keywords: keloidal morphea, keloidal scleroderma, nodular morphea, nodular scleroderma.
  • Analysis of patient demographics, lesion characteristics, comorbidities, and treatment outcomes.

Main Results:

  • The patient presented with nodular lesions on the chest, plaques on the abdomen, and sclerodactyly.
  • Literature review revealed a majority of affected patients were African American females with trunkal nodular lesions.
  • Sclerodactyly was common; 28% had pulmonary involvement, 63% were ANA positive, and 10% were anti-SCL-70 positive.

Conclusions:

  • Keloidal scleroderma is a rare condition that requires careful differential diagnosis from keloids and scars.
  • Methotrexate demonstrated efficacy in reducing lesion firmness and preventing new lesion formation in the reported case.
  • Further research is needed to establish optimal treatment strategies for this rare scleroderma variant.