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Clinical Features of Miller-Fisher Syndrome in Pregnancy

Masanori Ono1, Hideki Sato2, Mayu Shirahashi1

  • 1Department of Obstetrics and Gynecology, Saitama City Hospital, Midori, Saitama 336-8522, Japan.

Case Reports in Obstetrics and Gynecology
|December 24, 2015
PubMed

Insights

Miller-Fisher syndrome (MFS), a rare Guillain-Barré syndrome variant, presents with ophthalmoplegia, ataxia, and areflexia. This case report details MFS in early pregnancy, a previously unreported association, emphasizing accurate diagnosis.

Area of Science:

  • Neurology
  • Rare Diseases

Background:

  • Miller-Fisher syndrome (MFS) is a rare variant of Guillain-Barré syndrome (GBS).
  • MFS is characterized by ophthalmoplegia, ataxia, and areflexia, with higher incidence in Asia.
  • Differential diagnoses include Wernicke's encephalopathy, myasthenia gravis, and brainstem stroke.

Purpose of the Study:

  • To describe the clinical features of MFS in a pregnant patient.
  • To highlight the importance of accurate diagnosis in pregnant patients with MFS.

Main Methods:

  • Case report of a pregnant woman diagnosed with MFS in early pregnancy.
  • Review of clinical features and diagnostic considerations.

Main Results:

  • The case presents the first reported instance of MFS associated with pregnancy.
  • The patient's history and diagnostic tests were crucial for accurate diagnosis.

Conclusions:

  • The association between MFS and pregnancy is reported for the first time.
  • Accurate diagnosis in pregnant patients requires careful history taking and appropriate testing.

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