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Kidney Injury Molecule-1 and Cardiovascular Diseases: From Basic Science to Clinical Practice

Branislava Medić1, Branislav Rovčanin2, Gordana Basta Jovanović3

  • 1Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Dr Subotica Starijeg 1, 11129 Belgrade, Serbia.

Biomed Research International
|December 24, 2015
PubMed

Insights

Kidney injury molecule-1 (KIM-1) shows promise for early detection of cardiovascular disease risk in patients with kidney problems. Monitoring KIM-1 may improve outcomes for those with cardiorenal conditions.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarker Discovery

Background:

  • Cardiovascular disease (CVD) is a leading cause of death in patients with kidney dysfunction, particularly acute kidney injury (AKI).
  • Early identification of patients with combined renal and cardiovascular risk is crucial for timely intervention and improved outcomes.
  • Kidney Injury Molecule-1 (KIM-1) is emerging as a significant biomarker for kidney damage.

Purpose of the Study:

  • To review current literature on KIM-1's role in the early diagnosis and prognosis of cardiovascular diseases.
  • To highlight KIM-1's potential as a predictive marker in cardiorenal conditions.

Main Methods:

  • Literature review of animal and human studies on KIM-1.
  • Analysis of KIM-1's established role in acute tubular necrosis (ATN) and AKI prediction.
  • Exploration of KIM-1's relevance in cardiorenal syndromes and related cardiovascular conditions.

Main Results:

  • KIM-1 is recognized as a key marker for acute tubular necrosis (ATN) and a predictor of AKI development and prognosis.
  • The US FDA has approved KIM-1 as an AKI biomarker for preclinical drug development.
  • Emerging data underscore KIM-1's importance in monitoring various renal diseases and cardiovascular conditions, including cardiorenal syndrome and heart failure.

Conclusions:

  • KIM-1 is a promising biomarker for the early diagnosis and prediction of clinical outcomes in specific cardiovascular diseases.
  • Further research into KIM-1 monitoring could enhance patient management in cardiorenal settings.

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