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High-Sensitivity Troponin I and Rhythm Outcome after Electrical Cardioversion for Persistent Atrial Fibrillation

Anja Wiedswang Horjen1, Sara Reinvik Ulimoen, Ingebjørg Seljeflot

  • 1Department of Medical Research, Vestre Viken Hospital Trust, Bx00E6;rum Hospital, Drammen, Norway.

Cardiology
|December 25, 2015
PubMed

Insights

High-sensitivity troponin I (hs-TnI) did not predict atrial fibrillation (AF) recurrence after cardioversion. hs-TnI levels remained stable in patients maintaining sinus rhythm and were unaffected by candesartan treatment.

Area of Science:

  • Cardiology
  • Biomarkers
  • Electrophysiology

Background:

  • Persistent atrial fibrillation (AF) poses a significant clinical challenge.
  • Cardioversion is a common procedure to restore sinus rhythm.
  • Predictors of long-term rhythm outcome after cardioversion are crucial for patient management.

Purpose of the Study:

  • To investigate if high-sensitivity troponin I (hs-TnI) predicts long-term rhythm outcome after cardioversion for persistent AF.
  • To determine if maintaining sinus rhythm or candesartan treatment reduces hs-TnI levels.

Main Methods:

  • A double-blind, placebo-controlled study involving 171 patients undergoing electrical cardioversion for AF.
  • Patients were randomized to receive candesartan or placebo.
  • hs-TnI levels were measured at baseline and study end in successfully cardioverted patients.

Main Results:

  • hs-TnI was detectable in all subjects, with a median baseline of 5.3 ng/l.
  • Baseline hs-TnI did not predict rhythm outcome 6 months post-cardioversion.
  • Candesartan treatment did not affect hs-TnI levels, nor did maintaining sinus rhythm.

Conclusions:

  • hs-TnI is not a predictor of AF recurrence after cardioversion.
  • Maintaining sinus rhythm for 6 months does not alter hs-TnI levels.
  • Candesartan does not influence hs-TnI levels in this context.
Abstract

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