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The Antisense Transcriptome and the Human Brain.

James D Mills1, Bei Jun Chen1, Uwe Ueberham2

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Journal of Molecular Neuroscience : MN
|December 25, 2015
PubMed
Summary
This summary is machine-generated.

Antisense transcripts, RNA molecules transcribed from both DNA strands, are abundant in the human brain. This review explores their identification, regulation, and roles in brain function and disease.

Keywords:
Antisense transcriptsHuman brainRNA-SeqTranscriptome

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The cellular transcriptome comprises diverse RNA species, dynamically influenced by environmental and disease factors.
  • The human brain exhibits a particularly rich transcriptome, with a notable abundance of antisense transcripts.
  • Antisense transcripts arise from transcription of both DNA strands, overlapping with sense transcripts.

Purpose of the Study:

  • To review antisense transcription specifically within the human brain.
  • To elucidate the regulatory functions of antisense transcripts in brain health and disease.
  • To discuss methodologies for identifying and quantifying these transcripts.

Main Methods:

  • Review of existing literature on antisense transcription in the brain.
  • Discussion of techniques for antisense transcript identification and quantification.
  • Analysis of documented examples and regulatory mechanisms.

Main Results:

  • Antisense transcription is a widespread phenomenon in the brain.
  • Various regulatory roles for antisense transcripts in gene expression have been identified.
  • Specific examples illustrate their contribution to brain function and pathology.

Conclusions:

  • Antisense transcripts play significant roles in the complex biology of the human brain.
  • Understanding these transcripts is crucial for comprehending brain function and neurological disorders.
  • Further research into antisense transcript regulation can yield therapeutic insights.