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Candida cell wall mannan: a polysaccharide with diverse immunologic properties.

J E Domer1

  • 1Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana.

Critical Reviews in Microbiology
|January 1, 1989
PubMed
Summary

Mannan influences biological functions through various mechanisms. However, using purified mannan is crucial for understanding its specific regulatory activities and resolving complex biological phenomena.

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Area of Science:

  • Immunology
  • Glycobiology

Background:

  • Mannan exhibits diverse in vivo and in vitro biological activities, both specific and nonspecific.
  • Proposed mechanisms for mannan's regulatory effects include interference with polymorphonuclear leukocytes (PMNL) and monocyte function, and induction of T suppressor cells.

Purpose of the Study:

  • To investigate the specific mechanisms underlying mannan's biological activities.
  • To address the limitations posed by heterogeneous mannan preparations in previous studies.

Main Methods:

  • Analysis of mannan's biological functions using purified fractions separated by size or charge.
  • Comparison of activities between different mannan components.

Main Results:

  • Heterogeneous mannan mixtures contain components with opposing biological activities.

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  • Specific biological functions can be correlated with individual mannan fractions.

    • Conclusions:

    • Understanding mannan's precise regulatory mechanisms requires the use of homogeneous mannan preparations.
    • Further research with purified mannan is essential for complete resolution of its biological effects.