Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

302
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
302
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

1.2K
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
1.2K
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

429
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
429
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

662
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
662
Factors Influencing Drug Absorption: Anatomical Parameters01:23

Factors Influencing Drug Absorption: Anatomical Parameters

850
Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
850
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

308
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
308

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polydomain Liquid Crystal Elastomers with Mechanically Switchable Opacity for Thermal Shielding.

ACS polymers Au·2026
Same author

Valley-Dependent Emission Patterns Enabled by Plasmonic Nanoantennas.

ACS nano·2026
Same author

What Is the Right Chain Length? Liquid Crystalline Network Tuning by Molecular Design.

Macromolecules·2026
Same author

Longitudinal Structural and Microvascular Imaging of Mouse Retina After Optic Nerve Crush Using Temporal Speckle-Averaging Visible Light OCT.

Investigative ophthalmology & visual science·2025
Same author

Anisotropic light propagation in human brain white matter.

Neurophotonics·2025
Same author

Quasiannealed Monte Carlo method for light transport in strongly heterogeneous media.

Journal of the Optical Society of America. A, Optics, image science, and vision·2025

Related Experiment Video

Updated: Mar 28, 2026

Fabrication and Characterization of Disordered Polymer Optical Fibers for Transverse Anderson Localization of Light
09:19

Fabrication and Characterization of Disordered Polymer Optical Fibers for Transverse Anderson Localization of Light

Published on: July 29, 2013

12.0K

Path length enhancement in disordered media for increased absorption.

Rajeshkumar Mupparapu, Kevin Vynck, Tomas Svensson

    Optics Express
    |December 25, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Disordered dielectric slabs can enhance light absorption for photovoltaics. Even minimal scattering boosts optical path length significantly due to total internal reflection, optimizing absorption efficiency.

    More Related Videos

    Using Microwave and Macroscopic Samples of Dielectric Solids to Study the Photonic Properties of Disordered Photonic Bandgap Materials
    10:35

    Using Microwave and Macroscopic Samples of Dielectric Solids to Study the Photonic Properties of Disordered Photonic Bandgap Materials

    Published on: September 26, 2014

    12.8K
    Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers
    09:02

    Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers

    Published on: August 10, 2020

    8.0K

    Related Experiment Videos

    Last Updated: Mar 28, 2026

    Fabrication and Characterization of Disordered Polymer Optical Fibers for Transverse Anderson Localization of Light
    09:19

    Fabrication and Characterization of Disordered Polymer Optical Fibers for Transverse Anderson Localization of Light

    Published on: July 29, 2013

    12.0K
    Using Microwave and Macroscopic Samples of Dielectric Solids to Study the Photonic Properties of Disordered Photonic Bandgap Materials
    10:35

    Using Microwave and Macroscopic Samples of Dielectric Solids to Study the Photonic Properties of Disordered Photonic Bandgap Materials

    Published on: September 26, 2014

    12.8K
    Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers
    09:02

    Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers

    Published on: August 10, 2020

    8.0K

    Area of Science:

    • Optics
    • Materials Science
    • Condensed Matter Physics

    Background:

    • Disordered media offer unique light-matter interaction properties.
    • Enhancing light absorption is crucial for improving photovoltaic device efficiency.

    Purpose of the Study:

    • To investigate how scattering in dielectric slabs affects optical path length and light absorption.
    • To determine the optimal scattering conditions for maximum absorption enhancement.

    Main Methods:

    • Monte Carlo simulations of random walks to model light propagation.
    • Derivation of analytical expressions for path length enhancement.
    • Calculation of light absorption efficiency based on path length distributions.

    Main Results:

    • Significant optical path length enhancement observed even with minimal scatterers, attributed to total internal reflection.
    • Maximum light absorption enhancement achieved at an optimal scattering strength, between single and multiple scattering regimes.

    Conclusions:

    • Disordered dielectric slabs can be engineered for enhanced light absorption.
    • The findings provide guidance for developing efficient and cost-effective photovoltaic technologies.