Related Experiment Video
Updated: Mar 28, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis, Antimicrobial and Anti-inflammatory Activity of Some New Benzoxazinone and Quinazolinone Candidates
Maher Abd El-Aziz El-Hashash1, Mohammad Emad Azab, Rasha Abd El-Aziz Faty
1Chemistry Department, Faculty of Science, Ain Shams University.
Abstract:
Benzoxazinones and quinazolinones have a wide spectrum of biological activity. In this paper we focused on studying the antimicrobial and anti-inflammatory activities of some newly synthesized benzoxazinone and quinazolinone derivatives. Thus we prepared 2-[α-benzoylaminostyryl]-6,8-dibromo-3,1-benzoxazin-4(H)-one 2 which underwent a reaction with primary and secondary amines, and hydrazine hydrate to give compounds 3, 4 and 5, respectively. Treatment of 2 with hydroxylamine hydrochloride, formamide and/or NaN3/AcOH afforded compounds 7, 8, 11 and 12, respectively. Also, compound 2 reacted with maleic anhydride, aromatic hydrocarbons and/or active methylene compounds to produce compounds 13, 15a-c and 16, respectively. Most of the newly synthesized compounds showed significant antimicrobial and anti-inflammatory activities comparable to ampicillin, mycostatine and indomethacin positive controls.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Gene Regulation in Microbial Communities: Quorum Sensing
Radical Chain-Growth Polymerization: Overview
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Reactions at the Benzylic Position: Oxidation and Reduction

