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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Updated: Mar 28, 2026

Guided Endodontics: Three-Dimensional Planning and Template-Aided Preparation of Endodontic Access Cavities
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Regenerative endodontics--Creating new horizons.

Harnoor Dhillon1, Mamta Kaushik1, Roshni Sharma1

  • 1Department of Conservative Dentistry and Endodontics, Army College of Dental Sciences, Secunderabad, India.

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
|December 25, 2015
PubMed
Summary

Regenerative endodontics offers a promising alternative to traditional root canal therapy for damaged dental pulp. This innovative field uses stem cells and tissue engineering to promote pulp regeneration, aiming to improve treatment success rates.

Keywords:
dentin formationendodonticspulp regenerationrevascularizationtissue engineering

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Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
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Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

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Area of Science:

  • Dentistry
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Dental pulp trauma can cause inflammation and necrosis, often requiring root canal treatment.
  • Conventional root canal treatments have a 10%-15% failure rate despite advancements.
  • Regenerative endodontics presents a novel approach to treat inflamed and necrotic pulp.

Purpose of the Study:

  • To introduce the fundamental concepts of regenerative endodontics.
  • To outline treatment protocols within this emerging field.
  • To explore future research directions in pulp regeneration.

Main Methods:

  • Utilizes principles from endodontics, cell biology, and tissue engineering.
  • Employs mesenchymal stem cells, growth factors, and organ tissue culture.
  • Investigates modalities like blood clot induction for revascularization, scaffold-assisted regeneration, and pulp implantation.

Main Results:

  • Successful treatment of damaged pulp tissue has been achieved using regenerative endodontics principles.
  • The field is in its early stages but shows significant potential.
  • Highlights the dynamic and evolving nature of regenerative endodontics.

Conclusions:

  • Regenerative endodontics offers an ideal treatment for inflamed and necrotic pulp.
  • This field has the potential to revolutionize endodontic treatment.
  • Further research is crucial to fully realize the capabilities of regenerative endodontics.