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European Academies Advise on Gain-of-Function Studies in Influenza Virus Research
Robin Fears1, Volker ter Meulen2
1Biosciences Programme, EASAC, German National Academy of Sciences, Halle (Saale), Germany Gain of Function Working Group, EASAC, German National Academy of Sciences, Halle (Saale), Germany.
Journal of Virology
|December 25, 2015
Summary
Gain-of-function (GoF) research on pandemic pathogens is controversial. EASAC provides recommendations on GoF research management, ethics, safety, and publication to guide responsible scientific advancement.
Area of Science:
- Microbiology
- Biosafety and Biosecurity
- Bioethics
Background:
- Gain-of-function (GoF) research, which involves modifying pathogens to understand transmissibility, presents ethical and safety challenges.
- Potentially pandemic pathogens require careful consideration due to their inherent risks.
- International scientific consensus is needed for the responsible conduct of GoF studies.
Purpose of the Study:
- To summarize the European Academies Science Advisory Council (EASAC) consensus recommendations on GoF research.
- To highlight key areas for GoF research governance, including review, management, ethics, and biosafety.
- To emphasize the need for global dialogue and harmonized approaches to GoF research.
Main Methods:
- Analysis of the EASAC consensus report on GoF research.
- Identification of core recommendations concerning GoF research review and management.
- Synthesis of EASAC's advice on bioethical considerations, benefit-risk assessment, and biosafety/biosecurity.
Main Results:
- EASAC proposes a framework for GoF research, emphasizing self-regulation and harmonization.
- Recommendations cover ethical review, robust benefit-risk assessments, and stringent biosafety/biosecurity measures.
- The report addresses the sensitive issue of publishing information on GoF research.
Conclusions:
- A layered approach integrating existing stringent rules and new responsibilities is crucial for GoF research oversight.
- Continued global engagement and debate are essential to refine and implement effective governance strategies for GoF studies.
- Adherence to EASAC recommendations can foster responsible innovation in understanding pandemic pathogen risks.
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