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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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Related Experiment Video

Updated: Mar 28, 2026

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

Long Noncoding RNAs in Atherosclerosis.

Liguo Jian¹, Dongdong Jian, Qishan Chen

¹Department of Cardiology, The Second Affiliated Hospital of Zhengzhou University.

Journal of Atherosclerosis and Thrombosis

|December 25, 2015

Summary

This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are key regulators in biological processes. This review highlights lncRNAs involved in atherosclerosis development, offering insights for future research.

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A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

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Last Updated: Mar 28, 2026

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Area of Science:

Molecular Biology
Cardiovascular Research
Genetics

Background:

Long noncoding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides with diverse regulatory functions.
Atherosclerosis is a complex cardiovascular disease involving inflammation and lipid accumulation in artery walls.
Emerging evidence implicates lncRNAs in the cellular mechanisms underlying atherosclerosis.

Purpose of the Study:

To review and summarize the current understanding of lncRNAs in atherosclerosis.
To highlight specific lncRNAs that influence atherogenesis.
To provide a foundation for future research into lncRNA-targeted therapies for atherosclerosis.

Main Methods:

Literature review of studies investigating lncRNAs in atherosclerosis.
Analysis of lncRNA roles in key cell types involved in atherosclerosis (VSMCs, ECs, macrophages).
Synthesis of findings on lncRNA involvement in atherogenic processes.

Main Results:

Numerous lncRNAs have been identified that modulate atherosclerosis progression.
lncRNAs impact vascular smooth muscle cell proliferation and migration.
lncRNAs influence endothelial cell function and inflammatory responses in macrophages.

Conclusions:

lncRNAs are critical players in the pathogenesis of atherosclerosis.
Understanding lncRNA functions offers potential therapeutic targets for cardiovascular disease.
Further investigation into lncRNA mechanisms is warranted to develop novel treatment strategies.