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Association between acute motor axonal neuropathy and septic shock due to Acinetobacter baumannii

Lucia Toscani1, Diletta Guarducci2, Sabrina Matà3

  • 1Department of Neurology, S. Maria Annunziata Hospital, Florence, Italy.

Le Infezioni in Medicina
|December 25, 2015
PubMed

Insights

Acute motor axonal neuropathy (AMAN) can follow septic shock. This case suggests Acinetobacter baumannii infection may trigger AMAN through molecular mimicry, similar to Campylobacter jejuni.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Acute motor axonal neuropathy (AMAN) is a rare neurological disorder.
  • The exact causes of AMAN are not fully understood.
  • Campylobacter jejuni infection is a known potential trigger for AMAN through molecular mimicry.

Observation:

  • This report details a case of AMAN occurring after septic shock.
  • The patient's septic shock was caused by Acinetobacter baumannii.
  • Acinetobacter baumannii shares structural similarities with Campylobacter jejuni.

Findings:

  • The lipopolysaccharide structure of Acinetobacter baumannii mimics that of Campylobacter jejuni.
  • This structural similarity suggests a potential role for Acinetobacter baumannii in AMAN pathogenesis.
  • A hypothesis of molecular mimicry is proposed for this case.

Implications:

  • Acinetobacter baumannii may be an underrecognized cause of AMAN.
  • Understanding the role of bacterial mimics in autoimmune neuropathies is crucial.
  • This finding could lead to new diagnostic or therapeutic strategies for AMAN.

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