Related Experiment Video
Updated: Aug 16, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
Published on: June 24, 2018
Noncollagenous matrix proteins and their role in mineralization
1Laboratory for Ultrastructural Biochemistry, Hospital for Special Surgery, New York, NY 10021.
Abstract:
Improved technologies have led to the isolation of a large number of noncollagenous matrix proteins from the mineralized connective tissues. These proteins have been postulated to have many functions, but few of their suggested roles have been verified. Many of the noncollagenous matrix proteins are thought to regulate the deposition of hydroxyapatite mineral. In this review the current information on the role of these proteins in the mineralized and mineralizing connective tissues is presented along with a synopsis of the methods currently being used to elucidate these functions.
Related Concept Videos
The Extracellular Matrix
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Matrix Proteoglycans and Glycoproteins
Role of Matrix Metalloproteases in Degradation of ECM
A...
The Bone Matrix
Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

