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Updated: Mar 28, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
A palladium-catalyzed coupling reaction of aryl nonaflates, sulfur dioxide, and hydrazines
Yuanyuan An1, Hongguang Xia2, Jie Wu3
1Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China. jie_wu@fudan.edu.cn.
Abstract:
A facile route to synthesise N-aminosulfonamides through a palladium-catalyzed coupling reaction of aryl nonaflates, sulfur dioxide, and hydrazines is reported. This transformation proceeds in the presence of Pd(OAc)2/XantPhos, and TBAB in 1,4-dioxane at 80 °C, leading to the corresponding N-aminosulfonamides in moderate to good yields. The reaction scope has been demonstrated, and good functional tolerance is observed. A plausible mechanism is proposed through the insertion of sulfur dioxide.
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