Related Experiment Video
Updated: Mar 28, 2026
Detection of Rare Mutations in CtDNA Using Next Generation Sequencing
Published on: August 24, 2017
ESR1 Mutations in Breast Cancer: Proof-of-Concept Challenges Clinical Action
Guowei Gu1, Suzanne A W Fuqua2
1Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.
Abstract:
Wang and colleagues demonstrate that digital droplet PCR (ddPCR) identified ESR1 mutations in 7% of primary breast cancers. ESR1 mutations were also readily detected in metastatic tissues and circulating tumor DNA in the blood. These results suggest that ddPCR may be amendable for monitoring tumor burden, and to predict relapse. See related article by Wang et al., p. 1130.
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