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First results about recovery of walking function in patients with intensive care unit-acquired muscle weakness from
Jan Mehrholz1, Simone Mückel2, Frank Oehmichen3
1Wissenschaftliches Institut, Private Europäische Medizinische Akademie der Klinik Bavaria in Kreischa, Kreischa, Germany Department of Public Health, Medizinische Fakultät 'Carl Gustav Carus', Technische Universität Dresden, Dresden, Germany.
Objectives:
To describe the time course of recovery of walking function and other activities of daily living in patients with intensive care unit (ICU)-acquired muscle weakness.
Design:
This is a cohort study.
Participants:
We included critically ill patients with ICU-acquired muscle weakness.
Setting:
Post-acute ICU and rehabilitation units in Germany.
Measures:
We measured walking function, muscle strength, activities in daily living, motor and cognitive function.
Results:
We recruited 150 patients (30% female) who fulfilled our inclusion and exclusion criteria. The primary outcome recovery of walking function was achieved after a median of 28.5 days (IQR=45) after rehabilitation onset and after a median of 81.5 days (IQR=64) after onset of illness. Our final multivariate model for recovery of walking function included two clinical variables from baseline: the Functional Status Score ICU (adjusted HR=1.07 (95% CI 1.03 to 1.12) and the ability to reach forward in cm (adjusted HR=1.02 (95% CI 1.00 to 1.04). All secondary outcomes but not pain improved significantly in the first 8 weeks after study onset.
Conclusions:
We found good recovery of walking function for most patients and described the recovery of walking function of people with ICU-acquired muscle weakness.
Trials Registrations Number:
Sächsische Landesärztekammer EK-BR-32/13-1; DRKS00007181, German Register of Clinical Trials.
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