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Interstitial cystitis and the urethral syndrome: a possible answer.
E G Wilkins1, S R Payne, P J Pead
1Public Health Laboratory; Department of Urology, St Mary's Hospital, Portsmouth.
British Journal of Urology
|July 1, 1989
Summary
This study suggests an infection may cause interstitial cystitis (IC) and urethral syndrome. Identifying fastidious bacteria in bladder tissue and urine samples supports this link, highlighting the need for early diagnosis.
Area of Science:
- Urology
- Infectious Diseases
- Microbiology
Background:
- Interstitial cystitis (IC) diagnosis relies on specific clinical criteria.
- The etiology of IC remains incompletely understood, with infection being a potential factor.
Purpose of the Study:
- To investigate a possible infective etiology for interstitial cystitis.
- To explore the relationship between urethral syndrome and interstitial cystitis.
Main Methods:
- Bacteriological cultures were performed on bladder biopsies, urine samples (catheter and midstream), and urethral swabs.
- Methods were employed to detect both aerobic pathogens and fastidious bacteria.
- Histological examination of bladder biopsies was conducted.
Main Results:
- Bacteria were isolated from 12 of 20 patients with interstitial cystitis.
- Fastidious bacteria, including Gardnerella vaginalis and Lactobacillus sp., were identified in several isolates.
- Histological findings consistent with IC were observed in all patients.
Conclusions:
- The findings support an infective etiology for interstitial cystitis.
- Urethral syndrome and interstitial cystitis may represent different stages of the same infectious disease process.
- Early diagnosis and treatment of infection are crucial for patients presenting with these conditions.
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