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Updated: Mar 28, 2026

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
Published on: February 17, 2023
Red-Light-Responsive Supramolecular Valves for Photocontrolled Drug Release from Mesoporous Nanoparticles
1Max Planck Institute for Polymer Research , Ackermannweg 10, D-55128 Mainz, Germany.
Abstract:
Red-light-responsive supramolecular valves constructed by tetra-ortho-methoxy-substituted azobenzene (mAzo) and β-cyclodextrin (β-CD) were used to control drug release from mesoporous silica nanoparticles (MSNs). Doxorubicin (DOX) was used as a model drug and loaded into nanopores of mAzo modified MSNs. β-CD formed supramolecular valves with mAzo by host-guest interaction and closed the nanopores. Red light was able to open the supramolecular valves and induce DOX release even in deep tissue.
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