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Related Experiment Video

Updated: Mar 28, 2026

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death
09:14

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death

Published on: October 18, 2024

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Ex vivo lung perfusion.

Jeremie Reeb1, Marcelo Cypel1

  • 1Division of Thoracic Surgery, Toronto Lung Transplant Program, University of Toronto and Toronto Lung Transplant Program, Latner Thoracic Surgery Research Laboratories, Toronto, ON, Canada.

Clinical Transplantation
|December 25, 2015
PubMed
Summary
This summary is machine-generated.

Ex vivo lung perfusion improves lung quality for transplantation, addressing donor shortages and poor outcomes. This technique offers a new era in lung preservation for end-stage lung disease patients.

Keywords:
donation after cardiac deathex vivo lung perfusionlung assessment/reconditioning/repairlung transplantationmarginal donor lungorgan preservationorgan procurementprimary graft dysfunction

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Area of Science:

  • Thoracic Surgery
  • Transplantation Medicine
  • Medical Devices

Background:

  • Lung transplantation is a critical treatment for end-stage lung disease.
  • Challenges include donor scarcity and primary graft dysfunction impacting outcomes.
  • Novel preservation methods are needed to improve lung graft viability.

Purpose of the Study:

  • To review the rationale, techniques, and clinical applications of ex vivo lung perfusion (EVLP).
  • To discuss available EVLP devices and protocols.
  • To highlight EVLP's potential in advancing lung preservation and transplantation success.

Main Methods:

  • Review of existing literature on ex vivo lung perfusion.
  • Analysis of EVLP techniques, including the Toronto protocol.
  • Examination of clinical data and available devices for EVLP.

Main Results:

  • Ex vivo lung perfusion enables detailed assessment and enhancement of donor lungs.
  • Various EVLP devices and protocols are being utilized globally.
  • Clinical experience demonstrates the potential of EVLP to improve lung graft utilization and outcomes.

Conclusions:

  • Ex vivo lung perfusion represents a significant advancement in lung preservation.
  • EVLP facilitates better donor lung selection and quality improvement.
  • This technique holds promise for a new era in lung transplantation, overcoming current limitations.