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Updated: Mar 28, 2026
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
Published on: August 14, 2017
ALPPS Procedure for Extended Liver Resections: A Single Centre Experience and a Systematic Review
Marco Vivarelli1, Paolo Vincenzi1, Roberto Montalti1
1Hepatobiliary and Abdominal Transplantation Surgery, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy.
The Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) technique significantly increases future liver remnant volume, enabling resection of inoperable liver tumors. However, postoperative morbidity and mortality are considerable, influenced by patient age and liver condition.
Area of Science:
- Hepatobiliary Surgery
- Surgical Oncology
- Gastroenterology
Background:
- The Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) is a novel two-stage surgical procedure for liver resection.
- It is indicated for patients with extended primary or secondary liver tumors where the future liver remnant (FLR) is insufficient for immediate resection.
Purpose of the Study:
- To present a single-center experience with the ALPPS technique.
- To systematically review the existing literature on ALPPS.
Main Methods:
- Prospective assessment of patients for ALPPS since January 2013.
- Systematic literature search of PubMed, Scopus, and Cochrane Library Central.
Main Results:
- ALPPS was completed in 9 patients (mean age 60 ± 8 years) for various liver tumors.
- FLR volume increased significantly from 21.1% to 32.2% (p < 0.001) between stages.
- One postoperative death and 11 complications in 6 patients were observed; overall survival was 89% at 12 months.
Conclusions:
- The ALPPS technique enhances resectability for initially inoperable liver tumors.
- Postoperative morbidity is high, consistent with literature data.
- Age, liver fibrosis, and biliary stenting are risk factors for morbidity and mortality.
