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[Homografts in the human brain. Current data].

J C Gautier

    Bulletin De L'Academie Nationale De Medecine
    |January 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Human brain grafting, particularly for Parkinson's disease, has a history dating back to 1982. While experimental research shows promise, clinical application requires caution due to efficiency and ethical concerns.

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    Pharmacogenetics·1996

    Area of Science:

    • Neuroscience
    • Transplantation Biology
    • Medical Ethics

    Context:

    • Human nervous system grafting has been performed since 1982, primarily for Parkinson's disease.
    • Experimental research has explored new approaches, including hydroxydopamine and MTPP, expanding the field.
    • Grafts of adrenal medulla and fetal substantia nigra have been used in hundreds of patients.

    Purpose:

    • To review the theoretical basis and experimental work underpinning human central nervous system grafting.
    • To discuss the application of brain grafting in various neurological and endocrine disorders.
    • To highlight the challenges and ethical considerations of applying experimental research to human patients.

    Summary:

    • The review covers the historical and experimental foundations of human neural grafting, initiated around the turn of the century.

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  • Clinical applications in Parkinson's disease, Huntington's chorea, spinal cord injury, and schizophrenia are discussed.
  • Animal studies demonstrate successful counteraction of endocrine disorders via hypothalamic and pre-optic area transplants.

    • Impact:

    • Clinical results necessitate significant caution, emphasizing the need for further research into efficacy.
    • Experimental research holds high interest but faces substantial ethical and legal questions regarding human application.
    • The review underscores the critical gap between promising animal research and safe, effective human therapeutic strategies.