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Intraventricular Gangliogliomas: A Review
G Lakshmi Prasad1, Rajinder Kumar1, Nilesh Kurwale1
1Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
World Neurosurgery
|December 25, 2015
Summary
Intraventricular gangliogliomas (GG) are rare brain tumors. Complete surgical removal offers excellent outcomes, though the need for adjuvant therapy remains debated for these challenging neoplasms.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Neuropathology
Background:
- Gangliogliomas (GG) are typically benign primary brain tumors found in young adults.
- Intraventricular location of gangliogliomas is exceptionally rare, presenting unique diagnostic and therapeutic challenges.
Observation:
- A case of multicentric intraventricular ganglioglioma in a 15-year-old girl with hydrocephalus is presented.
- Imaging revealed two distinct lesions in the anterior and posterior third ventricles.
- The patient underwent successful surgical excision in two stages following shunt insertion.
Findings:
- A literature review identified 21 cases of pure intraventricular gangliogliomas.
- Increased intracranial pressure was the most common presenting symptom; seizures occurred in 25% of cases.
- Gross total resection was achieved in 90% of cases, with 10% experiencing recurrence and 10% mortality.
Implications:
- Intraventricular gangliogliomas are rare but manageable with complete surgical excision.
- The optimal role of adjuvant therapy for intraventricular gangliogliomas requires further investigation.
- This study contributes to understanding the clinicoradiologic characteristics of intraventricular versus parenchymal gangliogliomas.
