Impact of Modafinil Add-on with Atypical Anti-psychotics on Excessive Daytime Drowsiness

Atypical antipsychotic drugs are known to cause many side effects which include daytime drowsiness. So many add on drugs are tried to reduce the same.

72 patients who were on atypical antipsychotic drugs were randomly assigned to either Modafinil or placebo and were followed for a period of 12 weeks. Daytime drowsiness, was taken at baseline, week 3, and at week 12 by using VAS, EDD scales.

The results were analyzed and showed that the Modafinil add on therapy significantly reduced the daytime Drowsiness.

Modafinil could be a potential candidate in selected group of patients to decrease some of the unwanted adverse events like daytime drowsiness produced by atypical antipsychotics.