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Sperm Centrosomes: Kiss Your Asterless Goodbye, for Fertility's Sake
Gerald Schatten1, Tim Stearns2
1Departments of Ob-Gyn-Repro Sci, Cell Biology & Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Current Biology : CB
|December 26, 2015
Abstract:
Centrosomes are reduced to their cores in sperm. Emerging molecular explanations for centrosome construction have now helped to elucidate the mechanism of their destruction in sperm. Since centrosome inaccuracies cause aneuploidies responsible for cancers, birth defects and infertility, this new insight into centrosome behavior has broad implications.