Related Experiment Video
Updated: Mar 28, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Cardiovascular Simulation of Heart Failure Pathophysiology and Therapeutics
Darshan Doshi1, Daniel Burkhoff2
1Columbia University Medical Center/New York-Presbyterian Hospital, New York, New York.
Abstract:
Mathematical modeling and simulation allows for an in-depth examination of the cardiovascular system and provides the opportunity to develop deeper understanding. This review summarizes recent efforts at modeling the cardiovascular system and how these models have been useful in providing greater comprehension of the pathophysiology of heart failure, explaining the hemodynamic impact of various heart failure devices, predicting the hemodynamic effects and clinical outcomes of certain heart failure clinical trials, and perhaps aiding in patient selection for new therapies. The potential future use of these models in clinical research and clinical practice are also discussed.
Related Concept Videos
Pathophysiology of Heart Failure
Heart Failure II: Pathophysiology
Heart Failure VI: Adjunct Therapies
Heart Failure V: Medical Management
Heart Failure I: Introduction
Heart Failure IV: Classification and Diagnostic Evaluation

