Corneal stromal demarcation line after accelerated crosslinking using continuous and pulsed light

To evaluate and compare the depth of corneal stromal demarcation line after accelerated collagen crosslinking (CXL) using continuous and pulsed light ultraviolet-A (UVA) exposure.

Department of Ophthalmology, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.

Retrospective case series.

Patients with progressive keratoconus were assigned to 1 of 2 treatment protocols using the same irradiation device for accelerated CXL. Patients assigned to Group A received accelerated CXL using continuous UVA light exposure at 30 mW/cm(2) for 4 minutes. Patients assigned to Group B received accelerated CXL using pulsed UVA light with 8 minutes (1 second on/1 second off) of UVA exposure at 30 mW/cm(2) and energy dose of 7.2 J/cm(2). One month after surgery, corneal stromal demarcation line depth was measured by 2 independent observers using anterior segment optical coherence tomography (AS-OCT).

A total of 60 patients were assessed. Corneal stromal demarcation line was easily identified on AS-OCT scans in all eyes by both observers. The mean depth of stromal demarcation line was 149.32 ± 36.03 μm in Group A and 213 ± 47.38 μm in Group B. The difference in stromal demarcation line depth between groups was statistically significant (P < .001).

Using accelerated CXL, the corneal stromal demarcation line was significantly deeper using pulsed rather than continuous light exposure.

No author has financial or proprietary interest in any material or method mentioned.