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Related Experiment Videos

The immunocompromised host.

M J Gorensek1

  • 1Department of Internal Medicine/Infectious Diseases, Cleveland Clinic Florida, Fort Lauderdale.

Dermatologic Clinics
|April 1, 1989
PubMed
Summary
This summary is machine-generated.

Infections are the leading cause of death in immunocompromised patients, often presenting as difficult-to-diagnose skin lesions. This review explores the diverse dermatologic manifestations of infection in these vulnerable individuals.

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Dermatology

Background:

  • Infections are the primary cause of mortality in immunocompromised individuals.
  • Reduced host defenses increase susceptibility to opportunistic pathogens, especially fungi.
  • Diminished inflammatory responses complicate infection diagnosis in these patients.

Purpose of the Study:

  • To review the spectrum of dermatologic manifestations of infections in immunocompromised patients.
  • To correlate skin lesions with underlying pathophysiologic mechanisms.
  • To highlight the variety of pathogens causing infections in this population.

Main Methods:

  • Literature review of reported infections in immunocompromised hosts.
  • Categorization of skin lesions based on four presumed pathophysiologic mechanisms.

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  • Analysis of diverse opportunistic pathogens identified in clinical cases.

    • Main Results:

    • Skin lesions are a common presentation, seen in up to one-third of infections.
    • Dermatologic manifestations can be the initial sign of systemic illness.
    • A wide array of pathogens contribute to these infections.

    Conclusions:

    • Understanding the diverse skin manifestations is crucial for diagnosing infections in immunocompromised patients.
    • Pathophysiologic mechanisms and specific pathogens inform diagnosis and management.
    • Early recognition of skin lesions can lead to timely intervention.