Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

634
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
634
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

4.9K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.9K
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

651
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
651
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.6K
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

561
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
561
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

760
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
760

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of the Qvella FAST system with downstream application of MALDI-TOF-MS, VITEK 2, and β-LACTA test for same-day identification and antimicrobial susceptibility testing of Gram-negative rods directly from positive blood cultures.

Microbiology spectrum·2026
Same author

Safety and Immunogenicity of 20-valent Pneumococcal Conjugate Vaccine According to Number and Timing of Primary Series Doses.

The Pediatric infectious disease journal·2026
Same author

Ivermectin for Critically and Noncritically Ill Hospitalized Patients With COVID-19: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP).

Critical care medicine·2026
Same author

Real-world effectiveness of 20-valent pneumococcal conjugate vaccine against all-cause outcomes among Medicare beneficiaries aged 65 years and older in the USA: a retrospective cohort study.

The Lancet. Infectious diseases·2026
Same author

[Comparison of the 2026 surviving sepsis campaign guideline and the 2025 German S3 sepsis guideline].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026
Same author

Diagnostic performance of β-(1→3)-D-glucan, two <i>Candida</i> antigen, and five anti-<i>Candida</i> antibody assays in ICU patients with sepsis and high risk for invasive candidiasis: a secondary endpoint of the CandiSep randomized clinical trial.

Journal of clinical microbiology·2026

Related Experiment Video

Updated: Mar 28, 2026

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
02:09

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Published on: December 20, 2024

1.2K

Overwhelming Postsplenectomy Infection: A Prospective Multicenter Cohort Study.

Christian Theilacker1,2, Katrin Ludewig3, Annerose Serr4

  • 1Center for Chronic Immunodeficiency.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|December 26, 2015
PubMed
Summary

Overwhelming postsplenectomy infection (OPSI) is often caused by Streptococcus pneumoniae, highlighting the need for improved prevention strategies. This study confirms pneumococci as the primary pathogen in severe sepsis post-splenectomy.

Keywords:
Streptococcus pneumoniaeaspleniaoverwhelming postsplenectomy infectionpneumococcal vaccinesplenectomy

More Related Videos

Robot-assisted Partial Splenectomy
08:34

Robot-assisted Partial Splenectomy

Published on: January 2, 2026

969
Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
04:40

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

Published on: November 4, 2022

1.5K

Related Experiment Videos

Last Updated: Mar 28, 2026

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
02:09

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions

Published on: December 20, 2024

1.2K
Robot-assisted Partial Splenectomy
08:34

Robot-assisted Partial Splenectomy

Published on: January 2, 2026

969
Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
04:40

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

Published on: November 4, 2022

1.5K

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Immunology

Background:

  • Recent studies challenge the assumption of pneumococci as the sole cause of severe post-splenectomy infections.
  • Defining causative pathogens and clinical features of overwhelming postsplenectomy infection (OPSI) is crucial.

Purpose of the Study:

  • To identify the primary pathogens responsible for severe sepsis and septic shock in patients following splenectomy.
  • To characterize the clinical presentation and risk factors associated with OPSI.

Main Methods:

  • A prospective cohort study was conducted across 173 German intensive care units.
  • Patients with and without asplenia experiencing severe community-acquired sepsis/septic shock were assessed for clinical and laboratory variables and survival.

Main Results:

  • Streptococcus pneumoniae was significantly more frequent in OPSI patients (42%) compared to controls (12%), often presenting as bloodstream infections.
  • OPSI patients had a higher incidence of malignancy history and lower BMI. Purpura fulminans was a notable complication.
  • Low pneumococcal vaccine coverage was observed in OPSI patients. Asplenia was independently associated with pneumococcal sepsis.

Conclusions:

  • Pneumococcal infections are confirmed as the leading cause of severe sepsis and septic shock after splenectomy.
  • The findings underscore the critical importance of pneumococcal disease prevention in asplenic individuals.