[Research progress of rectoanal inhibitory reflex]

Area of Science:

• Gastroenterology
• Neurogastroenterology
• Physiology

Background:

• The rectoanal inhibitory reflex (RAIR) plays a key role in anorectal function.
• Understanding RAIR has evolved significantly over the last 100 years.
• RAIR is essential for diagnosing Hirschsprung's disease.

Purpose of the Study:

• To review the research progress of the rectoanal inhibitory reflex (RAIR).
• To highlight the expanding knowledge of RAIR's role in various diseases.
• To emphasize the importance of RAIR in anorectal manometry.

Main Methods:

• Literature review of studies on RAIR over the past century.
• Analysis of RAIR's diagnostic applications, particularly for Hirschsprung's disease.
• Examination of RAIR's reflex pathways, neural regulation, and physiological functions.

Main Results:

• RAIR's role has been explored in depth, including its development and pathways.
• Specific RAIR performance patterns are recognized in several diseases beyond Hirschsprung's.
• RAIR is an indispensable component of anorectal manometry.

Conclusions:

• Research on RAIR has progressed substantially, enhancing diagnostic capabilities.
• RAIR is a critical indicator for a range of anorectal disorders.
• Continued study of RAIR is vital for advancing gastroenterological diagnostics and understanding.