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Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

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Enormous, rapidly growing breast mass.

Vivek Verma¹, Sanjay Muttineni², Rajesh R Kulkarni³

¹Department of Radiation Oncology, University of Nebraska Medical Center, 987521 Nebraska Medical Center, Ground Floor, Clarkson Tower, Omaha, NE, 68198, USA. vivek333@gmail.com.

|December 26, 2015

Summary

Rapidly enlarging breast masses, though uncommon, require prompt recognition. This case highlights a unique 36 cm phyllodes tumor, emphasizing the need for accurate diagnosis and treatment strategies for such large breast masses.

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Area of Science:

Oncology
Pathology
Surgical Oncology

Background:

Rapidly enlarging breast masses are a clinical concern for healthcare providers.
Early recognition and assessment are crucial for patient outcomes.

Observation:

A 51-year-old woman presented with sepsis secondary to a massive 36 cm exophytic breast/chest wall mass.
The patient had a history of psychiatric conditions.

Findings:

Histopathology revealed bland spindle cells with stromal overgrowth, consistent with a phyllodes tumor.
The patient underwent successful surgical resection, though margins were positive.

Implications:

Phyllodes tumors can present as enormous, exophytic masses.
Differential diagnosis for rapidly growing breast masses is essential.
Treatment typically involves surgery and potentially radiotherapy for high-risk cases.