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Updated: Mar 28, 2026
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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
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Vascular cognitive impairment and dementia
Philip B Gorelick1, Scott E Counts2, David Nyenhuis3
1Translational Science & Molecular Medicine, Michigan State University College of Human Medicine, Mercy Health Hauenstein Neurosciences, 220 Cherry Street SE, Grand Rapids, MI 49503, USA.
Biochimica Et Biophysica Acta
|December 26, 2015
Summary
Vascular factors significantly impact cognitive impairment, influencing both vascular cognitive disorders and Alzheimer's disease. Modifying cardiovascular and stroke risks offers promising strategies for preventing cognitive decline in later life.
Area of Science:
- Neurology
- Gerontology
- Public Health
Background:
- Vascular contributions to cognitive impairment are increasingly recognized.
- These factors are linked to vascular cognitive disorders and Alzheimer's disease.
- Cognitive impairment is a growing concern in aging populations.
Purpose of the Study:
- To review vascular pathogenesis and mechanisms in cognitive impairment.
- To examine neuropsychological and neuroimaging manifestations of cerebrovascular disease.
- To explore prevention strategies for cognitive impairment through risk modification.
Main Methods:
- Literature review of vascular contributions to cognitive impairment.
- Analysis of pathogenesis and mechanisms.
- Synthesis of clinical and imaging findings.
- Evaluation of prevention strategies based on risk factors.
Main Results:
- Vascular factors play a critical role in cognitive decline.
- Cerebrovascular disease presents with distinct neuropsychological and neuroimaging features.
- Cardiovascular and stroke risk modification shows potential for prevention.
Conclusions:
- Understanding vascular contributions is key to addressing dementia.
- Targeting vascular risk factors may prevent or delay cognitive impairment.
- Further research is needed to optimize prevention strategies.
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