Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

1.2K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.2K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.9K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.9K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.6K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An olfactory-prefrontal cortical circuit supports social recognition.

Research square·2026
Same author

Neurometabolites and Antipsychotic Response in Psychosis: A Mega-Analysis.

JAMA psychiatry·2026
Same author

Genetic interaction of <i>DISC1</i> and <i>Neuroligin</i> in regulation of glutamatergic synaptogenesis.

Frontiers in neuroscience·2026
Same author

Brain structural abnormalities in treatment-resistant schizophrenia.

Molecular psychiatry·2026
Same author

Soluble α2δ-1, altered in disease CSF, modulates network homeostasis and rescues deficits in a neuropsychiatric mouse model.

Neuron·2026
Same author

Cytomegalovirus-encoded immediate early 1 protein perturbs neural progenitor proliferation via interfering with host PML-DISC1 interaction.

The Journal of biological chemistry·2026

Related Experiment Video

Updated: Mar 28, 2026

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue
06:14

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue

Published on: May 8, 2018

9.3K

Accelerating stem cell trials for Alzheimer's disease.

Joshua G Hunsberger1, Mahendra Rao2, Joanne Kurtzberg3

  • 1Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC, USA.

The Lancet. Neurology
|December 26, 2015
PubMed
Summary

Induced pluripotent stem cells (iPSCs) offer new hope for Alzheimer's disease research, enabling personalized disease models and drug screening. Stem cell therapies are advancing, with clinical trials underway for potential Alzheimer's treatments.

More Related Videos

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

766
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

11.3K

Related Experiment Videos

Last Updated: Mar 28, 2026

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue
06:14

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue

Published on: May 8, 2018

9.3K
Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

766
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

11.3K

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Alzheimer's disease currently lacks effective cures or preventative measures.
  • Existing symptomatic treatments provide only limited, temporary relief.
  • Induced pluripotent stem cell (iPSC) technology presents a significant advancement.

Purpose of the Study:

  • To explore the potential of iPSC technology in creating personalized "disease-in-a-dish" models for Alzheimer's disease.
  • To investigate the use of iPSCs for studying disease mechanisms and identifying novel therapeutic targets.
  • To highlight the application of iPSCs in high-throughput screening of potential drug candidates.
  • To discuss the therapeutic potential of differentiated cell types derived from iPSCs.

Main Methods:

  • Development of personalized Alzheimer's disease models using iPSC technology.
  • Utilizing large panels of iPSCs for rapid screening of potential therapeutic compounds.
  • Investigating the production of various cell types from iPSCs for therapeutic applications.
  • Reviewing ongoing and planned clinical trials involving stem cell-based therapies for Alzheimer's disease.

Main Results:

  • iPSC technology facilitates the creation of patient-specific disease models.
  • iPSC-derived cells can be used for drug screening and mechanism studies.
  • Clinical trials investigating stem cell therapies for Alzheimer's disease have commenced.
  • Stem cell research shows promise for developing new Alzheimer's treatments.

Conclusions:

  • iPSC technology offers a powerful platform for Alzheimer's disease research and drug discovery.
  • Stem cell-based therapies are progressing towards clinical application for Alzheimer's disease.
  • Acceleration of human stem cell-based translational research is crucial for combating Alzheimer's disease.
  • While challenges remain, stem cell research holds significant promise for future Alzheimer's treatments.